李相芝

电话： 0532-58630890， 18653134260； E-Mail：xiangzhi@sdu.edu.cn

教育背景:

医学博士 2003.4-2007.3 日本千叶大学（Chiba University）医学院  

理学硕士 2000.4-2002.3 日本熊本大学（Kumamoto University）自然科学研究科  

农学士  1992.9-1997.6 中国农业大学 动物医学院

工作经历:

2018.5-现在 山东大学生命科学学院 教授，博导

2011.8-2018.4 山东大学医学院 教授，博导

2007.4-2011.8 美国密西根大学（University of Michigan）医学院 博士后

2002.4-2007.3 日本理化学研究所 (RIKEN) 生命医科学研究中心（IMS）JRA

1999.4-2002.3 日本国立水俣病研究中心(NIMD） 特别研究员

荣誉与奖励:

1. 2011，山东大学齐鲁青年学者

2. 2013，教育部新世纪优秀人才

3. 2019，山东大学杰出中青年学者

社会兼职：

1. 中国整形美容协会干细胞研究与应用分会常务理事

2. 山东细胞生物学会常务理事

3. 中国抗癌协会肿瘤分子医学专委会委员

4. 中国细胞生物学学会细胞工程与转基因生物分会委员

5. 中华医学会医学细胞生物学分会青年委员

研究方向:

1. 干细胞分化的表观遗传学调控

2. 疾病发生发展的表观遗传学调控

3. 哺乳动物胚胎发育的分子机制

主持课题:

1. 2017-2020 通过DNA 复制维持表观遗传信息的分子机制 国家重点研发计划“政府间国际科技创新合作”重点专项

2. 2017-2018 Polycomb在乳腺癌发生发展中的作用及其调控机制 分子肿瘤学国家重点实验室开放基金

3. 2016-2019 组蛋白乙酰转移酶MOF在肝脏发育和疾病中的调控作用及其机制 国家自然科学基金

4. 2015-2017肿瘤联合靶向光动力治疗及其生物学调控机理 山东大学交叉学科建设经费

5. 2019-2021 高等医学研究院交叉学科开放课题

6. 2020-2021 中国地质科学院横向课题

7. 2014-2016   教育部“新世纪优秀人才”支持计划

8. 2012-2015  组蛋白乙酰转移酶MOF在胚胎干细胞自我更新和分化中的作用 国家自然科学基金

9. 2011-2015 肿瘤发生发展的表观遗传学调控 齐鲁青年学者学科建设经费

10. 2019-2023 山东大学杰出中青年学者学科建设经费

11. 2023-2025 山东省自然科学基金

12. 2023-2024 山东省中科低碳科技有限公司生命周期低碳发展综合管控关键技术研究

代表性论文:

1. Chen J, Liu D, Chen B, Yang Y, Zhu H, Li D, Liu K, Zhu L, Liu H, Li M, Zhang X, Li X*., The histone acetyltransferase Mof regulates Runx2 and Osterix for osteoblast differentiation. Cell Tissue Res. 2023; 393(2): 265-279.

2. Guo X, Liang K, Xia L, Zhang X, Liu J, Wang C, Li J, Li X, Hou X, Chen L.，Mof plays distinct roles in hepatic lipid metabolism under healthy or non-alcoholic fatty liver conditions. iScience. 2023; 26(12):108446.

3. Liu H, Zhang X, Zhao Z, Zhu H, Li D, Yang Y, Zhao W, Zhang F, Wang Y, Zhu L, Ding Z, Li X*, CNST is Characteristic of Leukemia Stem Cells and is Associated With Poor Prognosis in AML. Front Pharmacol. 2022; 13:888243.

4. Guo R, Liang Y, Zou B, Li D, Wu Z, Xie F, Zhang X, Li X*., The Histone Acetyltransferase MOF Regulates SIRT1 Expression to Suppress Renal Cell Carcinoma Progression. Front Oncol. 2022; 12:842967.

5. Zhang X, Yang Y, Li D, Wu Z, Liu H, Zhao Z, Zhu H, Xie F, Li X*., MOF negatively regulates estrogen receptor α signaling via CUL4B-mediated protein degradation in breast cancer. Front Oncol. 2022; 12:868866.

6. Wang M, Liu H, Zhang X, Zhao W, Lin X, Zhang F, Li D, Xu C, Xie F, Wu Z, Yang Q, Li X*., Lack of MOF Decreases Susceptibility to Hypoxia and Promotes Multidrug Resistance in Hepatocellular Carcinoma via HIF-1α. Front Cell Dev Biol. 2021; 9:718707.

7. Wang M, Liu H, Zhang X, Zhao W, Li D, Xu C, Wu Z, Xie F, Li X*., Lack of Mof reduces acute liver injury by enhancing transcriptional activation of Igf1. J Cell Physiol. 2021; 236(9):6559-6570.

8. Yu L, Wang M, Yang Y, Xu F, Zhang X, Xie F, Gao L, Li X*., Predicting therapeutic drugs for hepatocellular carcinoma based on tissue-specific pathways. PLoS Comput Biol. 2021; 17(2): e1008696.

9. Guo X, Cui C, Song J, He Q, Zang N, Hu H, Wang X, Li D, Wang C, Hou X, Li X, Liang K, Yan F, Chen L., Mof acetyltransferase inhibition ameliorates glucose intolerance and islet dysfunction of type 2 diabetes via targeting pancreatic α-cells. Mol Cell Endocrinol. 2021; 537:111425.

10. Li D, Yang Y, Chen B, Guo X, Gao S, Wang M, Duan M, Li X*., MOF Regulates TNK2 Transcription Expression to Promote Cell Proliferation in Thyroid Cancer. Front Pharmacol. 2020; 11:607605.

11. Guo X, Li D, Song J, Yang Q, Wang M, Yang Y, Wang L, Hou X, Chen L, Li X *., Mof regulates glucose level via altering different α-cell subset mass and intra-islet glucagon-like peptide-1, glucagon secretion. Metabolism. 2020；109:154290.

12. Zhai Y., Ma X., Gao F., Zhang T., Hong J*., Zhang X., Yuan X., Li X*.,  Is energy the key to pursuing clean air and water at the city level? A case study of Jinan City, China. Renew Sust Energ Rev. 2020; 134, 110353. (一区Top）

13. Yang Y, Guan J, Shaikh A, Liang Y, Sun L, Wang M, Li D, Qiu C, Li X *.， Histone Acetyltransferase Mof Affects the Progression of DSS-Induced Colitis. Cell Physiol Biochem. 2018; 47: 2159-2169.

14. Liang Y, Yang Y, Guo R, Gao S, Guo X, Li D, Wang M, Koseki H, Li X*. PCL2 regulates p53 stability and functions as a tumor suppressor in breast cancer. Sci Bull. 2018; 63: 629–639.（一区Top）

15. Xu XF, Jing X, Ma HX, Yuan RR, Dong Q, Dong JL, Han XF, Chen ZY, Li XZ *, Wang Y *. miR-181a Participates in Contextual Fear Memory Formation Via Activating mTOR Signaling Pathway. Cereb Cortex. 2018; 28(9):3309-3321.  

16. Zhao WB, Wang M, Gao S, Shaikh AS, Chen J, Li XZ *. The histone acetyltranseferase KAT8 regulates cell differentiation by suppression of MN1 in AML. Br J Haematol. 2018; 182(2):276-279.

17. Ye L, Xie F, Hong J*, Yang D, Ma X, Li X*. Environmental burden mitigation potential of oil field gas-assisted coal-to-olefin production. Energy. 2018; 157, 1015-1024. (IF=7.147，一区)

18. Pan J, Yang Y, Fang W, Liu W*, Le K, Xu D, Li X*, Fluorescent Phthalocyanine–Graphene Conjugate with Enhanced NIR Absorbance for Imaging and Multi-Modality Therapy. ACS Appl. Nano Mater. 2018; 1(6): 2785-2795.

19. Yang Y, Han X, He J, Guo X, Shaikh A, Sun L, Gao S, Liang Y, Wang M, Li X *. The histone acetyltransferase MOF is required for the cellular stress response. Sci Bull. 2017; 62: 1559–1561.（ 一区Top）

20. Hong J*, Chen Y, Wang M, Ye L, Qi C, Yuan H, Zheng T, Li X *. Intensification of municipal solid waste disposal in China. Renew Sust Energ Rev. 2017; 69:168-176. (一区Top）

21. Wang Y, Zhang X, Tang W, Lin Z, Xu L, Dong R, Li Y, Li J, Zhang Z, Li X, Zhao L, Wei JJ, Shao C, Kong B, Liu Z. miR-130a upregulates mTOR pathway by targeting TSC1 and is transactivated by NF-κB in high-grade serous ovarian carcinoma. Cell Death Differ. 2017; 24(12):2089-2100.

22. Li Q, Wang D, Hao S, Han X, Xia Y, Li X, Chen Y, Tanaka M, Qiu CH. CD169 Expressing Macrophage, a Key Subset in Mesenteric Lymph Nodes Promotes Mucosal Inflammation in Dextran Sulfate Sodium-Induced Colitis. Front Immunol. 2017; 8:669-695.

23. Xu C, Hong J*, Chen J, Han X, Lin C, Li X*. Is biomass energy really clean? An environmental life-cycle perspective on biomass-based electricity generation in China. J Clean Prod. 2016; 133 (1): 767-776. ( 一区 Top)

24. Hao S, Han X, Wang D, Yang Y, Li Q, Li X, Qiu CH.，Critical role of CCL22/CCR4 axis in the maintenance of immune homeostasis during apoptotic cell clearance by splenic CD8α(+) CD103(+) dendritic cells. Immunology. 2016; 148(2):174-86.  

25. Li X*, Yang Y, Xu X, Xu C, Hong J *. Air pollution from polycyclic aromatic hydrocarbons generated by human activities and their health effects in China. J Clean Prod. 2016; 112: 1360-1367.

26. Hong J, Shi W, Wang Y, Chen W, Li X*. Life cycle assessment of electronic waste treatment. Waste Manag. 2015; 38:357-65.  

27. Yang Y, Han X, Guan J, Li X*. Regulation and function of histone acetyltransferase MOF. Front Med. 2014; 8(1):79-83.

28. Hong J*, Zhang Y, Xu X, Li X*. Life-cycle assessment of corn-based and cassava-based ethylene production. Biomass Bioenerg. 2014; 67: 304-311.  

29. Li X, Li L, Byun J, Pandey R, Kuick R, Gardner K, Qin Z, Dou Y. The histone acetyltransferase Mof is a key regulator of the embryonic stem cell core transcription network. Cell Stem Cell. 2012; 11(2)：163-178. (Highlighted & Previewed by Cell Stem Cell) （一区Top）

30. Li X, Isono K, Yamada D, Endo TA, Endoh M, Shinga J, Mizutani-Koseki Y, Otte AP, Casanova M, Kitamura H, Kamijo T, Sharif J, Ohara O, Toyada T, Bernstein BE, Brockdorff N, Koseki H. Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genes. Mol Cell Biol. 2011; 31(2):351-364.

31. Katoh H, Qin ZS, Liu R, Wang L, Li W, Li X, Wu L, Du Z, Lyons R, Liu CG, Liu X, Dou Y, Zheng P, Liu Y., FOXP3 orchestrates H4K16 acetylation and H3K4 trimethylation for activation of multiple genes by recruiting MOF and causing displacement of PLU-1. Mol Cell. 2011; 44(5):770-84. （一区Top）

32. Li X, Corsa CA, Pan PW, Wu L, Ferguson D, Yu X, Min J, Dou Y. MOF and H4 K16 acetylation play important roles in DNA damage repair by modulating recruitment of DNA damage repair protein Mdc1. Mol Cell Biol. 2010; 30(22): 5335-5347.

33. Li X, Dou Y. New perspectives for the regulation of acetyltransferase MOF. Epigenetics. 2010; 5(3)：185-188.

34. Li X, Wu L, Corsa CA, Kunkel S, Dou Y. Two mammalian MOF complexes regulate transcription activation by distinct mechanisms. Mol Cell. 2009; 36(2): 290-301. (Highlighted paper; Previewed by Molecular Cell). （一区Top）

35. Ishii M, Wen H, Corsa CA, Liu T, Coelho AL, Allen RM, Cavassani KA, Li X, Lukacs NW, Hogaboam CM, Dou Y, Kunkel SL., Epigenetic regulation of the alternatively activated macrophage phenotype. Blood. 2009; 114(15):3244-54. （一区Top）

36. Cao F, Li X, Hiew S, Brady H, Liu Y, Dou Y.Dicer independent small RNAs associate with telomeric heterochromatin. RNA. 2009; 15(7):1274-81.

本课题组长期招聘博士后，欢迎对细胞生物学与表观遗传学感兴趣的同学报考硕士和博士。